Rho-stimulated Contractility Contributes to the Fibroblastic Phenotype of Ras-transformed Epithelial Cells
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چکیده
منابع مشابه
Rho-stimulated contractility contributes to the fibroblastic phenotype of Ras-transformed epithelial cells.
Oncogenic transformation of cells alters their morphology, cytoskeletal organization, and adhesive interactions. When the mammary epithelial cell line MCF10A is transformed by activated H-Ras, the cells display a mesenchymal/fibroblastic morphology with decreased cell-cell junctions but increased focal adhesions and stress fibers. We have investigated whether the transformed phenotype is due to...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 1997
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.8.11.2329